Journal: Acta Neuropathologica Communications

Article Title: Low-level blast exposure induces chronic vascular remodeling, perivascular astrocytic degeneration and vascular-associated neuroinflammation

doi: 10.1186/s40478-021-01269-5

Figure Lengend Snippet: Quantification of X-ray high-resolution micro-CT scanning. Parameters were determined using the software Vesselucida Explorer (v2018.1.1, MBF Bioscience LLC, Williston, VT, USA). Shown is total vascular length a , volume b , surface area c , length density d , the number of isolated vessels e , the longest vessel f , the number of branching nodes g , ending vessels h and the estimated total tissue volume i . Data is shown as violin plots. There were no statistically significant differences between the blast-exposed and sham-exposed (control) cohorts at any of the times studied post-exposure

Article Snippet: Three-dimensional reconstruction and morphological profiling of the cerebral vasculature was performed with the Bruker’s NRecon software or the Vesselucida 360 software (v2018.1.1, MBF Bioscience LLC, Williston, VT, USA) using data obtained from the micro-CT scans and reconstructing the respective three-dimensional vascular networks.

Techniques: Micro-CT, Software, Isolation, Control